Dr. Charlesnika Evans is leading the Quality Enhancement Research Initiative (QUERI) project, ‘Support and Enhancement of VA Guidelines to Prevent the Spread of CRE’. The main goal of this project is to support and enhance the implementation of new national VA guidelines to detect and prevent the spread of carbapenem-resistant Enterobacteriaceae in VA hospitals. CRE are gram-negative organisms resistant to a broad range of antimicrobial agents and have been associated with increased morbidity and up to 50% mortality. Investigators are working directly with VA operations partners including the VA Multidrug-resistant Organism (MDRO) Program Office to conduct a learning evaluation of implementation across different organization contexts. This study is one of three projects part of the larger QUERI program called ‘Combating Antimicrobial Resistance through Rapid Implementation of Available Guidelines and Evidence (CARRIAGE)’. The overall goal of CARRIAGE is to reduce the spread of antimicrobial resistance in VA healthcare facilities and beyond.